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Electron Microscopy Sciences

Specimen Preparation and Embedding Supplies

arrow13Nanopatterned Cell Cultureware

Parallel nanoscale topography aligns and matures cells and tissues

More mature cell and tissue cultures, faster

NanoSurface Cultureware structures cultured cells and tissues to improve physiological relevance. Shortly after plating, cells cultured in NanoSurface Cultureware exhibit enhanced structural and phenotypic development as compared to cells cultured in conventional culture dishes. NanoSurface topography induces cytoskeletal reorganization and cellular alignment. NanoSurface Cultureware is available in familiar standard formats, featuring No. 1.5 glass-bottom wells for high quality imaging.

NanoSurface plates rapidly structure and mature many cell types

  • CardiomyocytesNanoSurface Coverglass
  • Skeletal muscle cells
  • Smooth muscle cells
  • Endothelial cells
  • Human embryonic stem cells
  • Induced pluripotent stem cells
  • Mesenchymal stem cells
  • Fibroblasts
  • Epithelial cells
  • Cancer cells
  • And many more...

Biocompatible

  • Non-cytotoxic nanopatterened surface can be functionalized with a variety of ECM proteins

Surface Features

  • Substrate rigidity 6.69 MPa
  • Cell culture treated
  • Gamma sterile

High Quality Imaging

  • Compatible with high-magnification, high-NA transmitted light and fluorescence microscopy techniques
  • Nanotopography maintains migratory phenotypes of cancer cells
Conventional Dish   NanoSurface Dish
Without biomimetic surface topography, cardiomyocytes exhibit random orientation, disorganized contraction patterns, and immature functional phenotypes on conventional culture surface   On NanoSurface dishes, cardiomyocytes align to the surface topography, elongate in the direction of the nanopattern, and exhibit uniform anisotropic contraction patterns, with enhanced contractile force and conduction velocity
 
Human Endothelial Cells/Conventional   Human Endothelial Cells/NanoSurface
 
Vardiomyocytes/Conventional   Vardiomyocytes/NanoSurface

Biomimetic nanoscale surface topography imitates the aligned structure of the native extracellular matrix

NanoSurface nanopatterned culture surfaces provide a cellular microenvironment that mimics the aligned architecture of the native extracellular matrix, promoting cellular structural and functional development.

NanoSurface
The underlying matrix of the native myocardium has an aligned architecture (scale bar 10µm)
NanoSurface
NanoSurface CoverglassNanoSurface Coverglassarrow11A) NanoSurface Coverglass

NanoSurface coverglass features the same polymeric nanoscale topography found in NanoSurface culture dishes and plates.

Unpatterned control coverglass is also available: fabricated with same polymer and process as NanoSurface coverglass, without nanoscale topography.

  • 0.16 to 0.19 mm thick
  • 25mm diameter circular coverglass
  • Polymeric surface
  • Either NanoSurface parallel surface topography OR unpatterned control surface
64820-01 25 mm circular NanoSurface coverglass
No 1.5 thickness
800:800:600 nm surface topography
50/pk 500.00 Add to Cart
64820-02 25 mm circular NanoSurface coverglass
No 1.5 thickness
Unpatterned "flat" control surface
50/pk 500.00 Add to Cart
35mm NanoSurface Dish35mm NanoSurface Disharrow11B) 35 mm NanoSurface Dish

35mm glass-bottom dish with a polymeric nanopatterned surface topography.

  • Glass-Bottom
  • NanoSurface topography
  • 0.16 to 0.19 mm thick
  • 20mm Glass Diameter
  • Gamma Sterilized
  • Cell Culture Treated
64821-01 35 mm NanoSurface Dish
800:800:600 nm surface topography
10/pk 150.00 Add to Cart
64821-02 35 mm NanoSurface Dish
800:800:600 nm surface topography
100/pk 1,100.00 Add to Cart
64821-03 35 mm NanoSurface Dish
Unpatterned "flat" control surface
10/pk 150.00 Add to Cart
64821-04 35 mm NanoSurface Dish
Unpatterned "flat" control surface
100/pk 1,100.00 Add to Cart
24-Well NanoSurface Plate6-Well NanoSurface Plate96-Well NanoSurface Platearrow11C) NanoSurface Plates

6, 24 or 96-well glass-bottom plates with a polymeric nanopatterned surface topography.

  • Glass-Bottom
  • NanoSurface topography
  • 0.16 to 0.19 mm thick
  • 20mm Glass Diameter
  • Gamma Sterilized
  • Cell Culture Treated
64822-01 6-Well NanoSurface Plate each 100.00 Add to Cart
64822-02 6-Well NanoSurface Plate 10/pk 720.00 Add to Cart
64822-03 24-Well NanoSurface Plate each 150.00 Add to Cart
64822-04 24-Well NanoSurface Plate 10/pk 1,080.00 Add to Cart
64822-05 96-Well NanoSurface Plate each 225.00 Add to Cart
64822-06 96-Well NanoSurface Plate 10/pk 1,620.00 Add to Cart

Wells, Optical Bottom Plates, Cell Culture Inserts arrow13arrow13