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Electron Microscopy Sciences


info available in pdfinfo available in pdfinfo available in pdfarrow13Vibrating Microtomes

7000smz-2, 5100mz-Plus and 5100mz

Top-of-the-range, high precision, vibrating microtomes... the finest slicers in the world for all specimen preparation.

offerBuy a new Vibrating Microtome and get a $500 gift certificate for all of our consumables and supplies!

Vibrating Microtome 7000smz-2

The 7000smz-2 unit with a Z-axis deflection of Sub-Micron and a blade advance controllable to 10 microns/second. The 5100mz-Plus and 5100mz are very competitively priced high precision units with a Z-axis deflection of only 1-2 microns and a blade advance controllable to 10 microns/sec. On all units the section thickness step size is 0.001mm. The 7000smz-2 and 5100mz-Plus are supplied with their own Z-axis calibration verifier.

All types of sectioning is possible including sectioning for visual patching of neurological tissue, heart, and lung, and much more...

The effect of excessive Z-axis deflection on the health and viability of the tissue preparation has been much discussed since the publication of Jonas et al (2003) and the 7000smz-2 will now deliver perfect sections every time with sub-micron Z-axis deflection across a wide range of vibration speeds and amplitudes. The affordable 5100mz-Plus offers almost the same features with Z-axis deflection of 1-2 microns at all vibration speeds and amplitudes, which is less than most other microtomes on the market.

The all-new user interface is both easy to use and versatile. The 7000smz-2 and both 5100mz models offer similar operation at the press of a button. The versatility includes simple operation at the push of a button or a range of changeable and programmable parameters and a menu enables the settings of your own preferences.

The 7000smz-2 also gives you longevity of performance; in other words it not only gives submicron performance out-of-the-box, but the advance vibrating mechanism does not contain bearings and other components subject to wear. Consequently it will retain the sub-micron Z-axis deflection performance for years to come, giving you consistency in your biological preparation.

Tissue cooling is accomplished by the use of either an ice-water bath or an electronically comtrolled thermo-electric cooler. Other options include a LED cold light source and a magnifier or a stereoscope for clear observation whilst slicing.

The new 5100mz series Vibrating Microtomes share the user interface with the premium 7000smz-2, placing a wide range of adjustable parameters at the user's fingertips. Use in fully manual or the semi-automated "slice window" mode which automatically remembers the start and finish position of the slice.

5100 Series: Control box on umbilical cord ideal for operation in an isolated environment
5100 Series: Control box on umbilical cord ideal for operation in an isolated environment


The 5100-Plus is perfect for those who need to keep slices viable for longer, e.g. for electrophysiological field recordings. The user can calibrate the Z-axis deflection of the blade to 2µm with the adjustable blade holder and "optical" calibration device. Minimal Z-axis deflection reduces the "chatter" and minimizes damage to the slice surface, leading to greater viability of the cells on the slice surface.


The 5100mz is a very competitively priced, high precision, vibrating microtome which shares many features with the top of the range 7000smz series, such as the vibrating mechanism, the inner and outer tissue baths and the easy to use control system.

This new entry level microtome is perfect for techniques such as histology, organotype slice culture and low resolution imaging with a fixed blade holder and a mechanism Z-axis error rate of 5-8µm.

Vibrating Microtome 7000smz-2Vibrating Microtome 7000smz-2

Features at a Glance


  • Includes a Z-axis calibration unit
  • Minimal Z-axis deflection (less than 1µm) at all speeds and amplitudes
  • Z-axis blade adjust minimizer
  • Blade holder angle to user requirement
  • Set start and stop position of blade travel
  • Tissue sample automatically retracted before blade returns to start point
  • Full range of adjustable parameters with 8 customizable user profiles
  • Vibration speeds from 50 to 120Hz
  • Amplitudes from 0.5mm to 2.5mm
  • Controlled blade advance at 10 microns per sec
  • "Auto" programming by storage of the first slicing
  • Ice water bath easily removed for cleaning
  • Optional LED light and scope for clear observation
  • Leaf spring vibratory mechanism for optimal longevity and accuracy

5100mz-Plus and 5100mz:

  • Includes the Z-axis calibration unit (5100mz-Plus only)
  • Mechanism Z-axis error of less than 10µm
  • Vibration speeds from 50 to 80Hz
  • Amplitudes from 0.5mm to 1.5mm
  • Fine control of the blade advance (min. 0.1mm/sec)
  • Set start and stop position of blade travel
  • Remote controls allowing for sterile use in culture hood
  • Ice water bath easily removed for cleaning
  • Optional cold light and magnifier for clear observation
  • Optional Peltier cooled bath
  • Control handset allows full remote control


Specifications 7000smz-2 5100mz series
Section thickness step size 1µm 1µm
Vertical (Z-Axis) calibration device
'Opti-cal' is calibrated with metrology equipment traceable to National Standards
'Opti-cal' included as standard 'Opti-cal' included as standard for 5100mz-Plus
Optional extra for 5100mz
Optimal Z-axis Deflection Sub-µm (± 0.1µm) ≈ 5-8µm (2.0µm ± 0.1 with calibration upgrade kit)
Max specimen size 33x50x19 33x50x19
Maximum (vertical) travel of bath table 19mm 19mm
Memory to store section thickness Yes Yes
Multiple user settings 8 different 8 different
Cutting head advance speed while slicing From a minimum of -1.00mm/sec, through zero to a maximum of +1.00mm/sec From a minimum of -1.00mm/sec, through zero to a maximum of +1.00mm/sec
Cutting head advance speed resolution while slicing 0.01mm/sec 0.10mm/sec
Cutting head advance speed max (fast mode when not slicing) +/- 4.0mm/sec +/- 2.0mm/sec
Specimen retraction as blade retracts Yes Yes
Cutting head retraction speed (fast mode) 4.0mm/sec 2.0mm/sec
Operating Modes Manual, semi-auto 'slice window' or fully automated 'profile repeat' Manual or semi-auto 'slice window'
Blade oscillation frequency range (dependent on amplitude) 50-120Hz 50-80Hz
Frequency step size 5Hz 5Hz
Blade oscillation amplitude Minimum: 0.5mm (nominal)
Maximum: 2.5mm (nominal)
Minimum: 0.5mm (nominal)
Maximum: 1.5mm (nominal)
Amplitude step size 0.25mm (nominal) 0.5mm (nominal)
Cooling options Ice bath or optional Model 7610A Tissue Bath Cooler Ice bath or optional Model 7610A Tissue Bath Cooler
Power requirements 115VAC 60Hz or 230VAC 50Hz
90-264 VAC 50/60Hz
(switch mode PSU)
Power rating 100W 65W
Fuse rating (115v or 230v) T2A 250VAC T2A 250VAC
Light source 100-240VAC 3W mains connection Powered from 5100mz
Dimensions 420mm W x 400mm D x 270mm H (excluding light source and microscope) 350mm W x 450mm D x 350mm H (excluding magnifier/light source)
Weight 35kg 15kg
Packaged weight & dimensions Wooden crate 70 x 54 x 48cms, 55Kgs Box wt & dims TBA


info available in pdfTissue Bath Cooler
Model 7610-A Tissue Bath Cooler

1. Temperature Controlled Standard Tissue Bath

Product Description

The 7610-A Tissue Bath Cooler Unit is intended for use with our 7000 and 5100 range of vibrating microtomes. Unfixed brain slices sectioned at 4°C give better tissue preservation and are viable for longer in-vitro recordings. Additionally, some enzyme histochemical techniques give better staining results when sectioned at low temperatures.

Tissue Bath Mount
Tissue Bath Mount

The 7610 Series coolers use "Peltier" thermoelectric elements. The stainless steel tissue bath and mount are detachable to allow sterilization by autoclave if required.

The equipment comprises of a mains operated control unit, cooling element, tissue bath and specimen holder. The control unit houses a power supply and temperature control circuitry. The cooling element assembly consists of thermoelectric "Peltier" elements, temperature feedback sensors and a cold water fed heat exchanger.

Current from the power supply flows through the thermoelectric elements, which act as heat transfer units. Heat is drawn off, cooling the solution in the tissue bath. The heat generated by this process is removed by the water supply fed through the heat exchanger. The unit uses a proportional temperature control algorithm to maintain temperature stability. This will hold the bath temperature to within 0.5°C of the temperature set point. There will, however, be a small variation in temperature vertically through the bath. Experience will show the best temperature to be set for any given requirement and ambient temperature.

Product Specifications

Display Resolution:   0.1°C
Temperature Accuracy:   +/- .5°C
*Temperature Range:   +8°C to 0°C
Voltage Requirements:   230V 50Hz or 115V 60Hz
Power Rating:   60W
Inlet Fuse Rating:   2A

*Note that the actual temperatures achievable will be dependent upon the solutions used and local temperature conditions.

Integrally Mounted Cold Light Source
Model 7000-2-1

2. Integrally Mounted Cold Light Source

Model 7000-2-1

Product Description

To facilitate the careful slicing operation, it is most important that the progress of the blade through the tissue be clearly observed. This observation is used to ensure control of the speed of advance and of the oscillation of the blade. Two elements are required for clear observation, light and magnification.

Product Features

  • Ability to direct the light where needed with two flexible fiber optic light guides
  • Maintains temperature stability of the tissue or surrounding a.c.s.f.
  • Light Intensity is adjustable by a rotary dial knob
  • 20W/12V Halogen lamp
  • Integrally Mounted Magnifying Glass
    Model 7000-1-3
  • 2000 hour life approx
  • Fan and electronic power supply
  • Adjustable with potentiometer
  • Twin 500mm fiber optic light guides

3. Integrally Mounted Magnifying Glass

Model 7000-1-3

Product Description

For general global slices a magnifying glass offering approx 2x magnification is sufficient. However, if specific loci are under study then an inspection microscope is desirable. The binocular inspection microscope with 10x-40x magnification, a zoom of 1x-4x and a working distance of 80mm is ideal for the task.

Product Features

info available in pdfIntegrally Mounted Inspection Microscope
Model 7000-1-1
Model 7000-1-2
  • 115mm Diameter
  • 305mm Focal Length
  • 2x Magnification
Integrally Mounted Cold Light Source and Magnifying Glass
Model 5100-1-3

4. Integrally Mounted Inspection Microscope

Model 7000-1-1

5. Integrally Mounted Inspection Microscope

Model 7000-1-2
(x5 and x10)

6. Integrally Mounted Cold Light Source and Magnifying Glass

Model 5100-1-3

Product Description

Integrally Mounted Cold Light Source and Magnifying Glass
Model 5100-1-45

A magnifying glass for general global slices offering approximately 1.5x magnification. Integral cold light powered directly via the Model 51-mz Vibrating.

Upgrade Kit for 5100mz

Model 5100-1-45

Optional kit to upgrade the 5100mz to the 5100mz-Plus. Allowing the user to optimately calibrate the Z-axis deflection of the blade to 2± 0.1µm.


stainless steel microtome blades

Model 7550-1-C

stainless steel microtome blades

Model 7550-1-SS

1. Ceramic Blades

Model 7550-1-C

Product Description

The new blade holder design is now included with all Integraslice and Vibroslice instruments. 7550-1-C and 7550-1-SS are designed for new Integraslice instruments.

Product Features

  • Made from ultra hard zirconium
  • Honed by a process of "lapping" both sides of the single bevel to micron flatness
  • Great rigidity, hence a straight cutting edge
  • Prolonged slice life, especially in the most difficult of tissues such as young brain or very old brain
  • Inert and impervious to corrosion
  • Initial higher cost is offset by its longevity
  • Fits into a special blade holder now standard on both Integraslice and Vibroslice instruments

2. Stainless Steel Blades

Model 7550-1-SS

Product Features

  • Double beveled on both faces, honed to an acute cutting edge and hardened to 56 Rockwell.
  • Nevertheless, stainless steel is relatively soft and these blades are usually used once or at a maximum changed every day.
  • These blades are for use in specially designed blade holders for Vibroslice instruments manufactured prior to 2003.

Blade Specifications

  7550-1-C 7550-1-SS
Material Ceramic Stainless Steel
Dimensions 38mm x 7mm x 0.5mm 38mm x 9mm x 0.5mm
Geometry Single sided Double sided
Bevel Single bevel Double bevel
Honing Lapped edge Ground edge
Packaging 5 per pack 50 per pack
Buy a new Vibrating Microtome and get a $500 gift certificate for all of our consumables and supplies

Order Information

7000smz-2, 5100mz-Plus and 5100mz Vibrating Microtomes, Options, and Accessories

The finest vibration microtomes with sub-micron z-axis deflection at all speeds and amplitudes of vibration.

7000smz-2 Programmable Vibrating Microtome, includes demountable tissue bath and sample blades in stainless steel and ceramic, plus 'Opti-Cal' z-axis calibration device. 115V or 230V each 15,868.00 Add to Cart
5100mz-Plus Vibrating Microtome, includes demountable tissue bath and sample blades in stainless steel and ceramic. 115V or 220V each 12,500.00 Add to Cart
5100mz Vibrating Microtome, includes demountable tissue bath and sample blades in stainless steel and ceramic. 115V or 220V each 10,900.00 Add to Cart

Optional Accessories

Vibrating Microtomes, Options and Accessories
7610-A Standard Temp. Controlled Tissue Bath (autoclavable) and Controller each 2,789.00 Add to Cart
7000-1-3 Magnifying Glass, mounted to machine each 475.00 Add to Cart
7000-1-2 Inspection Microscope fixed x5-x10 each 997.00 Add to Cart
7000-1-1 Inspection Microscope zoom x20-x40 each 1,495.00 Add to Cart
7000-2-1 Cold Light Source each 1,237.00 Add to Cart
5100-1-45 Upgrade Kit for 5100mz each POR Quote
5100-1-3 Integrally Mounted Cold Light Source and Magnifying Glass for 5100mz-Plus and 5100mz each 650.00 Add to Cart

Spares and Accessories

7000-3-1A Tissue Bath Mount (additional price only - this mount comes standard with purchase of 7000smz-2, 5100mz-Plus or 5100mz) set 675.00 Add to Cart
7000-3-2 Stainless steel inner specimen bath set 225.00 Add to Cart
7000-4-1 Specimen Mount Only each 42.00 Add to Cart
7000-4-2 Tilting Tissue Mount each 225.00 Add to Cart
7000-5-3 Blade holder - special angle, includes right and left hand clamp screws, single-axis adjustment screw each 795.00 Add to Cart
7000-6-1 'Opti-Cal' Z-axis measurement, traceable to national standards each 1,225.00 Add to Cart
7000-7-1 Blade handling tool each 42.00 Add to Cart
7000-50-1 Tool kit - hexagonal drivers each 60.00 Add to Cart
7000-60-1 Transit crate, includes packaging expansion bags each 315.00 Add to Cart
7550-1-C Ceramic Blades 5/pk 395.00 Add to Cart
7550-1-SS Stainless steel blades - narrow, ultrasonically cleaned 50/pk 180.00 Add to Cart

Electron Microscopy Sciences is committed to offering you the most up to date equipment on the market. If you have any ideas or would like to see us make any changes in our line please let us know all ideas and suggestions are encouraged. We look forward to hearing from you.

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