The TC-1 Tissue Chopper is designed to facilitate the cutting of 100-1000 micron thick brain tissue slices for use in recording experiments. The chopper includes a guillotine arm with adjustments to assure blade alignment. The brain sample is moved in respect to the arm with a stage whose position can be read with 2 to 3 micron precision on a digital micrometer scale. The stage is made with a removable PTFE surface plate to facilitate cleaning.